The hair anti-irritation ritual
From environmental factors to aggressive hair dyes and unsuitable hair treatments, the scalp is subjected to multiple daily stresses that lead to chronic irritation. Tugging, itching and stinging sensations are reactions of discomfort revealing a delicate scalp.
SILAB proposes CAPICALM®, an anti-irritant active ingredient rich in purified fumitory glycans to protect sensitive scalp.
Through its soothing action, CAPICALM®:
- reduces the inflammatory reaction by limiting the release of key inflammation factors such as NF-kB et PGE2;
- protects thereby against external stresses by calming irritation and itching induced by chemical hair treatment.
Combining protection and comfort, CAPICALM® can be added to all hair treatment products for weakened scalp.
• Patented active ingredient « Made in France »• 100% natural origin
• Paraben free
• Proven safety
• Complied with Europe, USA, Japan and China regulation
➤ CAPICALM® limits inflammation phenomenon
• Effect of CAPICALM® on the activation of NF-kB
When subjected to inflammation induced by TNF-α, the phosphorylation and translocation of NF-kB in normal human keratinocytes are induced to a significant extent. Tested at 1% on keratinocytes treated with TNF-α, CAPICALM® reduces the phosphorylation of NF-kB by 43% (significant and dose-dependent effect; results available in the product file) and decreases the nuclear translocation of NF-kB (figures below).
CAPICALM® limits the inflammation phenomenon by reducing the activation of NF-kB.
➤ CAPICALM® limits inflammation phenomenon
• Effect of CAPICALM® on the release of prostaglandins E2 (PGE2)
When subjected to an inflammation induced by arachidonic acid, human keratinocytes secrete significantly more PGE2.
Tested at 1%, CAPICALM® significantly reduces the release of PGE2 by 48%, thereby limiting the inflammation phenomenon. This effect is dose-dependent.
➤ Anti-irritant effect of CAPICALM®
• Subjective evaluation
Self-evaluation questionnaire
CAPICALM®, added to a hair lightening treatment at 2%, is generally seen as more effective than the placebo.
94% of the volunteers found that CAPICALM® limited the sensations of heating and itching compared to the side treated with the placebo.
In addition, 88% of them consider that CAPICALM® is an anti-irritant and soothing product.
