Cellular defense regenerator
Introducing a New Anti-Ageing Peptide Designed to Actively Protect the Skin from the Inside
PerfectionPeptide P7 is a new biologically active hepta-peptide that stimulates the skin’s own self-defense mechanisms against oxidative stress.
Our cells respond to oxidative stress generated either internally or externally by activating the transcription factor Nrf2, which is a master switch in the cellular self-protection system. However, ageing down regulates this natural process.
In unstressed cells, Nrf2 activity is repressed by the Keap1 protein via a specific binding sequence. However, Mibelle Biochemistry has designed a heptapeptide that mimics this binding sequence and in doing so stimulates Nrf2 activity to enhance protection against reactive chemical species. For improved skin uptake, the peptide was incorporated into a soft sphere carrier system based on shea butter.
Cell culture assays and clinical studies have confirmed the capacity of PerfectionPeptide P7 to both boost Nrf2 activity and protect the skin from oxidative stress at the cellular level:
- DNA damage was significantly reduced.
- UV-induced formation of sunburn cells and the depletion of Langerhans cells were also significantly and greatly reduced.
Therefore, PerfectionPeptide P7 offers a unique strategy of ensuring protection against oxidative stress by activating Nrf2. In this way, the new anti-ageing peptide actively prevents both extrinsic and chronological ageing.
Claim Ideas for PerfectionPeptide P7
- Activates the skin’s self-protection capacity
- Fights both environmental and chronological ageing
- Protects DNA against oxidation
- Neutralises free radicals and empowers the skin’s own antioxidant capacity
Applications
- DD creams (daily defense)
- Protecting and regenerating skin care
- Age prevention products
- Sun protection
Formulating with PerfectionPeptide P7
- Recommended use level: 2 %
- Incorporation: For cold processes, dissolve PerfectionPeptide P7 into the aqueous phase. In hot/cold processes, add during the cooling phase below 45 °C.
- Thermostability: Temperatures of up to 45 °C for a short time will not affect the stability of PerfectionPeptide P7.
INCI / CTFA-Declaration
Acetyl sh-Heptapeptide-1 (and) Hydrogenated Lecithin (and) Glycerin (and) Butyrospermum Parkii (Shea) Butter (and) Phenethyl Alcohol (and) Ethylhexylglycerin (and) Aqua/Water
