Sun care – A preventative approach

Published: 18-Oct-2012

Sun exposure can have acute and chronic consequences for the skin with the indirect DNA damage from UVA radiation and direct DNA damage from UVB radiation. To combat photo-ageing and the impact on the skin including decreased collagen content and abnormal extracellular matrix (ECM) turnover, Lipotec has developed three active ingredients for molecular protection against free radicals and the prevention of premature ageing.

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Photo-ageing is a complex process which accelerates premature ageing on the skin but it can be controlled, as Marta Rull, Cristina Davi, Elena Cañadas, Wim Van Den Nest and Raquel Delgado explain


The sun’s rays have a proven ability to make individuals feel happy and motivated at the same time as offering other positive physiological effects: they are a primary source of vitamin D; they promote cell function and energy in the short term; and they help to regulate our natural biorhythm cycles. However, sun exposure can also have both acute and chronic consequences for the skin. Making up 95% of UV radiation, UVA radiation (320-400nm) can penetrate the epidermis and cause indirect DNA damage as a result of the production of reactive oxygen species (ROS) as well as single strand breaks in DNA and DNA–protein crosslinks, dermal damage and matrix remodelling including abnormal elastin fibres and increased collagen degradation and crosslinking.[1,2] Although UVB radiation (290-320nm) is mostly absorbed in the epidermis, it is more cytotoxic and mutagenic, directly inducing DNA damage.[3,4]

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