The benefits have been published in a peer reviewed journal - Journal of Cosmetic Dermatology, 2020 May 5, doi: 10.1111/jocd.13464
Sytheon collaborated with UC-Davis researchers on this study which delivers significant improvement in photoaging related skin benefits as well as skin sensitivity through well explored mechanisms of action.
The skin benefits were explored through a double-blind placebo controlled randomized clinical study.
There was a significant decrease in average wrinkle severity (p=0.019; Mean=-25.7% change), total wrinkle volume (p=0.003; Mean=-30.1 % change), pigment intensity (p=0.021; Mean=-25.6% change), and redness intensity (p=0.035; Mean=-20.7% change) in the AZ group by 8 weeks compared to the placebo.
Acetyl zingerone is well tolerated with daily use. No itching, burning, or stinging was noted by study participants.
Additionally, AZ treatment has maintained skin microbiome diversity with >20% increase in skin friendly staphylococcus epidermidis.