Truly Natural and Safe Ingredients to Human Skin from Regeron

Published: 25-Oct-2013

Regeron, Inc., a cosmeceuticals developer focusing on reverse-aging biotechnology, announces launching of novel ingredients...

Regeron, Inc., a pioneering cosmeceuticals developer focusing on reverse-aging biotechnology, announces launching of novel ingredients composed of combinations of biosynthetic human polypeptide growth factors (INCI: sh-Polypeptides) unique to Regeron, namely Clairesome-LY-C for skincare (anti-wrinkle; anti-itching; pro-healthier-complexion) and Repilosome-GY-C for hair-care(anti-hairloss; pro-hair-growth) that invite the world's top cosmetic brands companies for an exclusive supply agreement by the end of 2013.

Clairesome-LY-C contains Placental Lactogen(INCI: sh-Polypeptide-40) and VIP(Vasoactive Intestinal Peptide; INCI: sh-Polypeptide-71) in addition to the main active, Prolactin(INCI: sh-Polypeptide-28). Repilosome-GY-C contains EGF(Epidermal Growth Factor; INCI: sh-Oligopeptide-1) and VIP(Vasoactive Intestinal Peptide; INCI: sh-Polypeptide-71) in addition to the main active, hGH(Human Growth Hormone; INCI: sh-Polypeptide-7).

Each combination ingredient claims to be a most natural and safest to human skin, yet to show scientifically verifiable effectiveness (see below) to recommended uses, and commercially competitive and environmentally sustainable on the following grounds:

1)All Regeronsh-Polypeptides are present in or are parts of human tissues, and thus intrinsically compatible and biodegradable, therefore this class of ingredients should be the most natural as well as safest to human skin;

2)Sh-Polypeptides can not and in fact does not penetrate the epidermal barrier of intact human skin under normal conditions, therefore their topical application should be all the safer as these ingredients affect only the limited skin area in their direct contacts;

Cosmeceutical efficacies of sh-Polypeptides are subject to physiological interactions with as well as multi-level-feedback controls by human skin cells, thereby excessive or adverse biological effects are avoided or avoidable by design;

4)Placebo-controlled clinical tests with some sh-Polypeptide-containing formulations clearly revealed statistically significant differences in their cosmeceutical efficacies, and other sh-Polypeptide-containing formulations lacking clinical tests nevertheless attested their specific field-test efficacies track records as well;

5)Sh-Polypeptides from Regeron are all tested for their stabilities and efficacies for at least 15 months storage as individually specified;

6)Each combination sh-Polypeptides from Regeron demands extra-expensive preparations, yet reasonably and affordably priced for the high-end cosmetic products.

Regeron welcomes scientific discussions and challenges from different viewpoints to seek truth and to ultimately serve the consumers and the industry.

Truly Natural and Safe Ingredients to Human Skin from Regeron

Mechanism

We established drug delivery systems for our recombinant proteins to overcome the skin barrier. Generally, proteins are considered very difficult to go through epidermis because of their large molecular sizes. Another problem is proteins lose their activities easily in solution.
We developed methods for protein encapsulations so that the proteins can maintain their stabilities and bioactivities until delivered to the skin.

Truly Natural and Safe Ingredients to Human Skin from Regeron

Non-treated skin | His-hGH-treated skin | Clairesome-His-hGH-treated skin

Specifically targeting cells of the hair follicle through encapsulating active ingredients inside Clairesome, an effective cosmetic outcome as well as an efficient revitalizing signal transduction to critical cells of the skin can be attained.

Stability Test / Safety Test

- Stability of hGH in Clairesome-GY

Truly Natural and Safe Ingredients to Human Skin from Regeron

- In vitro Safety Evaluation of Clairesome-GY

Cultured cells were treated with serial dilution of the active ingredient (2mg/ml down to 0,03 mg/ml) for 24h + 4h. Treated cell viability was calculated and compared to untreated cells (positive control)

Experimental results:
• No toxic effect
• No irritating potential

Truly Natural and Safe Ingredients to Human Skin from Regeron

Source: Farcoderm data processing

Cosmeceutical Raw Materials


with Our World-First Cosmetic Ingredients

[Clairesome-LY-C]
(Actives: PRL=Human Prolactin; PL=Placenta Lactogen; VIP=Vasoactive Intestinal Peptide)
Specification : 100 ppm (Concentration of Growth Factors Combination)
Packing Size : 500g / 1Kg / 2Kg / 5Kg / 10Kg

Tradename
Clairesome-LY-C (PRL-GFs Combination )
Function
Anti-wrinkle, Complexion-bettering, Anti-atopic
Definition
Clairesome-LY-C : Sh-Polypeptide-28, 40, 71 ; Synthetic human prolactin with other GFs (growth factors) in aqueous solution
Properties
Sh-Pp-28, -40, or -71 gets carried into hair follicles with help of Clairesome and interacts with its respective receptors on the lining cells to exert its effects
Characteristics
Homogenous opaque yellowish aqueous solution
Point of interest
Hair follicle outer surface is an extension of epidermal basal layer and composed of progenitor cells derived from epidermal stem cells
INCI name
Clairesome-LY-C: Sh-Polypeptide-28, 40, 71; Sodium Phosphate;Lecithine; Sodium Chloride; Disodium EDTA; Water
Application
Skincare
Recommended use level
2%

Anti-wrinkle Age: 51

Truly Natural and Safe Ingredients to Human Skin from Regeron

After 12 weeks
Use level 2% Clairesome-LY / Controlled clinical test results

Anti-atopic Age:22

Truly Natural and Safe Ingredients to Human Skin from Regeron
After 8 weeks Use level 2% Clairesome-AI(P. lactogen) / Controlled clinical test results

Repilosome GY-C
Actives: hGH=Human Growth Hormone; EGF=Epidermal Growth Factor; VIP=Vasoactive Intestinal Peptide)
Specification : 100 ppm (Concentration of Growth Factors Combination)
Packing Size : 500g / 1Kg / 2Kg / 5Kg / 10Kg

Tradename
Clairesome-GY-C (hGH-GFs Combination )
Function
Anti-hairloss, Promoting hair-growth
Definition
Clairesome-GY-C : Synthetic human polypeptide-7(hGH), -71(VIP), synthetic human oligopeptide-1(EGF) inside protective liposomal carriers (Repilosome) in aqueous solution 
Properties
Sh-Pp-7, -71, or sh-Op-1 gets carried into hair follicles with help of Repilosome and interacts with its respective receptors on the lining cells to exert its effects
Characteristics
Homogenous opaque yellowish aqueous solution  
Point of interest
Hair follicle outer surface is an extension of epidermal basal layer and composed of progenitor cells derived from epidermal stem cells
INCI name
Repilosome-GY-C : Sh-Polypepyide-7, -71; Sh-Oligopeptide-1; Lecithin;Sodium Phosphate; Sodium Chloride; Disodium EDTA; Water
Application
Hair care
Recommended use level
1~2%

Increase of Proliferating (Hair-growing) Matrix Cells

Truly Natural and Safe Ingredients to Human Skin from Regeron

Buffer | Minoxidil 3% | Repilosome-GY (Use level 1%)

Cell counts


Average
SE
Buffer
39.9
2.3
3% Minoxidil
38.8
5.7
Repilosome-GY
56.1
3.1

Use level 2% Repilosome-GY / Pristeen Tonic

Truly Natural and Safe Ingredients to Human Skin from Regeron

13 Aug 2011 | 28 Oct 2011 | 10 Nov 2011

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