For many, Retinol is the gold standard in skincare - but at what cost?

Published: 6-Dec-2022

Novel marine retinoids proven to outperform Retinol in clinical studies without side effects

Retinol is renowned for stimulating cell renewal and collagen production, smoothing and plumping the skin from within. However, it poses a challenge to the consumer because of its proven instability, low penetration and potential for skin irritation, commonly known as ‘Retinol Burn’ or ‘Retinoid Dermatitis’.

This distinct from nonspecific irritant-contact dermatitis is characterised by erythema, scaling, dryness, burning sensation and pruritus and is mediated through receptor-mediated cell signalling.

More specifically, it has been demonstrated that the epidermal receptors RARα and RARγ are responsible for this so-called ‘Retinol Burn’, which takes place in the epidermis' stratum corneum (SC). These receptors have been proven to promote skin-based inflammation and dysregulation of skin barrier properties , increasing the degradation of corneodesmosomes and corneodesmosomal cadherins.

ALGAKTIV used its molecular knowledge and its proprietary biotechnological tools to develop a unique ingredient that changes the landscape for safer, high-performance retinoid ingredients: ALGAKTIV RetinART.

ALGAKTIV RetinART is obtained from a sustainably-sourced C. vulgaris and contains pure marine retinoids, which act as structural analogues of Retinoic Acid. Being naturally-occurring retinoids, these molecules have proven to bind only to the RARβ receptor to deliver the ultimate skin remodelling without any side effects.

ALGAKTIV RetinART’s selective RARβ modulation has shown to deliver outstanding anti-aging and anti-acne performance, beating 0.3% Retinol and 1% Bakuchiol in head-to-head clinical studies. Its retinol-like mechanism of action has also shown synergistic efficacy when combined with only 0.1% Retinol, beating a 0.5% Retinol cream in repairing and soothing photo-aged skin. Retinol has been considered a silver bullet for all skin care regimes, but ALGAKTIV RetinART’s unparalleled performance sets a new gold standard to reconcile performance and gentleness once and for all.

Learn more at:


Armstead, M., & Bard, S. (2021). How often can you use retinol? Retrieved December 1, 2022, from
Cleveland Clinic. (2022). Retinol: Cream, serum, what it is, benefits, how to use. Retrieved December 1, 2022, from,skin%20a%20fresher%2C%20plump%20appearance.
MacGregor, J. L., & Maibach, H. I. (2002). The specificity of retinoid-induced irritation and its role in clinical efficacy. Exogenous Dermatology, 1(2), 68-73. doi:10.1159/000058335
Milosheska, D., & Roškar, R. (2022). Use of retinoids in topical antiaging treatments: A focused review of clinical evidence for conventional and nanoformulations. Advances in Therapy, 39(12), 5351-5375. doi:10.1007/s12325-022-02319-7
Gericke, J., Ittensohn, J., Mihály, J., Dubrac, S., & Rühl, R. (2013). Allergen-induced dermatitis causes alterations in cutaneous retinoid-mediated signaling in mice. PLoS ONE, 8(8). doi:10.1371/journal.pone.0071244

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