Skin comfort is intimately related to the activity of the nervous; dermis and epidermis are highly innervated by neurons that respond to external and internal stimuli. Thanks to Neuroscience we can understand the relationship between skin and neurons, this scientific knowledge has leaded AntalGenics to develop Calmapsin, an innovative neurocosmetic ingredient to reduce sensitive and atopic skin signs.
Calmapsin is a neurocosmetic ingredient designed for the daily care of sensitive and irritated skin. Calmapsin has a 360º effect over sensory neurons and skin cells:
- Itchiness is mediated by the capsaicin receptor, that is expressed in sensory neurons and skin cells. Calmapsin, reduces the 99,6% of the capsaicin receptor’s activity, reducing itching signal from its origin. In volunteers, 15 minutes after application, Calmapsin reduced itch sensation to a 21,8% compared to the volunteers using placebo.
- Barrier function is disrupted in atopic and sensitive skin, this facilitates the entrance of pathogens and allergens inducing an inflammatory response in the skin. Calmapsin reverts the impairment in barrier function by inducing the expression of key genes for skin barrier. This effect is translated to an increase in moisturisation in the 48% of the volunteers using Calmapsin for 15 days.
- Oxidative stress accelerates skin ageing and atopic skin development, Calmapsin on the other hand, reduces a 40,4% of oxidative stress molecules in keratinocytes, protecting from oxidative stress damages better than ascorbic acid (vitamin C).
Calmapsin was awarded with the “Quality Innovation Award” in 2019. The multiple properties of Calmapsin allow simplicity in the formula composition due to the reduction of active ingredients used in formulations.
If you are interested in knowing more about Calmapsin and the neurocosmetic ingredients of AntalGenics, come to visit us during in cosmetics Global at stand R21.