Making sense of sensitisation

Andreas Natsch explains the mechanism, validation and implementation of Givaudan’s KeratinoSens assay for testing skin sensitisation

KeratinoSens, developed by the in vitro Toxicology Research team at Givaudan, was confirmed earlier this year as a recommended test for skin sensitisation by the EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM).

Since the 7th Amendment to the Cosmetics Directive came into force in March 2013, the use of animal testing for cosmetic ingredients has been banned in Europe, underlining the urgent need for alternative, reliable test methods. KeratinoSens and two other methods to test for the potential to cause skin allergy were subsequently put forward for validation by EURL ECVAM.

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