What is MyriTox?
MyriTox contains highly purified myricetin from blueberry. Myricetin (Figure 1) is a naturally occurring flavonol which is effective for scavenging ROS and protecting cells against oxidative stress. In addition, myricetin is effective for anti-wrinkle formation by interfering the SNARE-zippering complex formation as well as by inhibiting the axon membrane fusion rate. This eventually leads to inhibit wrinkle formation.
Molecular target of MyriTox is exactly same as that of BOTOX®. Unlike BOTOX® directly cleaving the SNARE proteins (irreversible mechanism), MyriTox only interrupts the process of SNARE-zippering complex formation (reversible mechanism). Thus, MyriTox is very safe for cosmetic use without any destruction of cellular molecules.
Clinical Study on Anti-Wrinkle Effect of MyriTox
A clinical study has been performed to evaluate anti-wrinkle effects of MyriTox on crow’s feet and nasolabial fold regions (by DermaPro Skin Research Center, Korea). 32 healthy subjects (average age; 47.2±5.4) used a facial cream containing 2% MyriTox twice a day for 6 weeks. The results showed that MyriTox can help effectively reduce existing wrinkles around both crow’s feet (Figure 2) and nasolabial fold (Figure 3) regions.
1) Myricetin suppresses oxidative stress-induced cell damage via both direct and indirect antioxidant action. Environ. Toxicol. Pharmacol. (2010) 29, 12-18.
2) Myricetin protects cells against oxidative stress-induced apoptosis via regulation of PI3K/Akt and MAPK signaling pathways. Int. J. Mol. Sci. (2010) 11, 4348-4360.
|INCI NAME||Glycerin, Water, Vaccinium Angustifolium (Blueberry) Fruit Extract|
|Dosage||Usage levels may vary from 1% to 5%, depending on the formulation. (Recommended dosage – 2%)|
|Formulation Guideline||Do not add when the formulation temperature is higher than 55°C. In the last step, cool the formulation temperature to lower than 55°C and then add to the formulation.|
|STORAGE & SHELF LIFE||MyriTox should be stored in the original container protected from light in a clean place at a room temperature. If stored under the recommended conditions, MyriTox remains stable for at least 3 years.|
Appearance ~ Brown liquid |
Odor ~ Characteristics
Solubility ~ Water-soluble
pH ~ 3.50 ~ 6.50 at 25°C
Specific Gravity ~ 1.10 ~ 1.30 at 25°C
MyriTox is a cosmetic ingredient specifically designed for anti-wrinkle effect. It can be used in various types of cosmetic application.