Since the Industrial Revolution in the 18th century, and increasing urbanisation, the relationship of humans with their environment has changed dramatically with a large part of the population moving to the cities, away from their ancestral constant interaction with nature.
This important moment also represented a relevant trigger in the prevalence of inflammatory disorders, such as allergies and eczemas, which leads us to deduce that the reduced exposure to nature contributes to increasing the risk of inflammatory skin conditions.
Research shows that people living in close contact with nature, similar to our ancestors, present a high bacterial diversity and have a high concentration of anti-inflammatory bacteria, associated with a healthier and more protected skin.
This finding led to the conclusion that the more exposed one is to modern lifestyles, the higher the reduction in the microbiome’s richness is, making the skin more prone to sensitivity and discomfort.
The new heptapeptide developed by Lipotec, FENSEBIOME peptide, assists in strengthening the skin of people exposed to urban environment by promoting microbiota balance and diversity as well as an increase in beneficial bacteria, all being characteristics of a healthier skin staying in higher contact with nature.
It also helps reinforce the double cutaneous barrier function and prevent dehydration, one of the main problems of sensitive skin.
The ability of FENSEBIOME peptide to modulate the skin microbiome was assessed on volunteers by means of a metagenomics study.
Urban female volunteers applied a cream containing 1% peptide solution on the cubital fossa of one arm and a placebo cream on the other, twice a day for 7 days.
Samples of the skin microbiota were obtained before and after the treatment and changes in the microbiome were assessed.
An increase in the bacterial diversity was observed on the treated skin, as well as a better balance of the microbiota leading to a healthier and protected skin.
FENSEBIOME peptide also helped reduce the TEWL levels, when applied before inducing irritation and evaluated 48 hours after damage, with a decrease of 27.8%.
The peptide assisted in boosting the skin’s own defence system by favouring the presence of beneficial bacteria and by improving the skin immune response and the physical barrier integrity as showed in vitro.
FENSEBIOME peptide can be incorporated into formulations aiming to strengthen the double cutaneous barrier function and to prevent dehydration as well as in prebiotic and probiotic-inspired skin care products intended to reinforce urban and sensitive skin.
The latest Lipotec peptide helps the skin regain its original strength to face urban life.
*FENSEBIOME peptide is owned by The Lubrizol Corporation or its affiliates.
