Compared with traditional salmon-derived PDRN, recombinant production offers superior structural consistency, higher purity, and enhanced batch-to-batch stability, ensuring reliable and reproducible performance in advanced skincare formulations.
Extensive in vitro studies demonstrate strong biological activity across skin repair, regeneration and anti-ageing pathways.
Key scientific highlights include:
- Enhanced skin repair – fibroblast migration increased to 131% of the control
- Collagen stimulation – type I collagen increased 1.5× and type III collagen increased 1.1×, outperforming conventional salmon-derived PDRN
- Anti-inflammatory activity – inhibition of inflammatory mediators IL-6 and TNF-α
- Formulation synergy – up to 93% cell migration within 24 hours when combined with hyaluronic acid
In vivo testing after 28 days of application at 0.1% concentration demonstrated visible skin improvements:
- Wrinkle area, length and number decreased by 7.44%, 11.44% and 46.67%
- Skin elasticity (R2) increased by 30.11%
- Skin firmness parameter (F4) decreased by 19.83%
- TEWL decreased by 17.37%, indicating improved barrier function
- Erythema index (EI) decreased by 12.40%
Together, these results position RJMPDRN REC as a next-generation vegan PDRN active that combines the efficacy of salmon-derived PDRN with the sustainability, safety and consistency of recombinant biotechnology.
