IBR-CalmDeAge: global anti-ageing relief of dark circles and rosacea
vasoconstriction, optimizing blood microcirculation, reducing irritation...
vasoconstriction, optimising blood microcirculation, reducing irritation
INCI name: Glycerin (and) Water (and) Phoenix Dactylifera (Date) Seed Extract
GLOBAL ANTI AGING reduction of DARK CIRCLES and RELIEF of ROSACEA
Allow your skin to rest, relax, revive and rejuvenate as under the shade of the date palm trees.
GLOBAL ANTI-AGEING
Derived from IBR-CalmDeAge's abilities:
- slow down cell proliferation (DORMINs: affecting intrinsic ageing, preserving youth via dormancy
- excellent anti-oxidation: affecting extrinsic ageing, preventing pre-mature ageing and photo ageing
DARK CIRCLE REDUCTION and ROSACEA RELIEF
- resulting from its alpha 2 adrenergic receptor agonist activity, leading to constriction of blood vessels, optimisation of blood flow and clearing of the skin
- significant ability to reduce irritation
Resulting in visible effects:
DIMINISHING DARK CIRCLES RELIEF of ROSACEA
STORY
Life from 2,000 year old date palm seed
By Steven Erlanger, The New York Times, June 13, 2005
The wind ruffles the leaves of the date sapling in its planter, and Dr. Elaine Soloway quickly shields it. "There's only one plant like this in the world, and I'm still worried about it," she says.
In 2005, Soloway, from Kibbutz Ketura in the Arava, germinated it from a 2,000 year old date seed found at Masada. For the past two millennia, since approximately the time of the Great Revolt of the Jews against the Romans, in 66-73 C.E., the seed lay dormant, until Soloway and her team breathed life into it, making it the oldest seed ever to germinate."
DATA
- Total Anti-oxidant activity of 100% IBR-CalmDeAge® is equivalent to 60-100 mM Trolox
- Total polyphenol equivalent of IBR-CalmDeAge is: 5000 - 10000mg/L Gallic Acid Equivalent
- Dormin-like effect - slow down cell proliferation
DARK CIRCLE REDUCTION and ROSACEA RELIEF
Vascular Microcirculation
Alpha 2 Adrenergic Receptors Activation and Vasoconstriction
The adrenergic receptors are metabotropic (i.e. influencing metabolism) G protein-coupled receptors (GPCR). Many types of cells possess these receptors, and the binding of an agonist (activator) will generally cause a sympathetic response.
An agonistic effect on the alpha-2 adrenergic receptor of smooth muscle cells may result in a vaso-constrictive effect - meaning, the blood vessels in which these cells and receptors are present will constrict and limit the pooling of blood which may result in improved, homogenous appearance of the skin in that area and reduction of the dark circles and rosacea symptoms.
IBR-CalmDeAge showed a significant activity as an alpha-2A adrenergic receptor agonist, potentially affecting the capillary blood vessels constriction.
Anti-irritation
A modified Het-Cam Irritation model was used to evaluate irritation reduction in pre-irritated tissue.
The key measure is the time to appearance of irritation symptoms.
IBR-CalmDeAge at 3% reduced pre-induced irritation by SLS by at least 50%.
THE ALLEVIATION OF DARK CIRCLES AND ROSACEA WAS DEMONSTRATED IN VIVO.
IBR-CalmDeAge, an extract from palm date (Phoenix dactylifera) seeds. IBR's extraction process preserves the inherent botanical capital of the date seed, delivering to the skin:
Influencing intrinsic aging by
• slow down of cell proliferation
• slow down of the biological clock
Influencing extrinsic ageing by
• anti-oxidant protection, thereby
• slowing down the effect of environmental aging factors
DARK CIRCLE and ROSACEA relief:
• Affecting microcirculation via constriction of blood vessels to optimize blood and serum flow and prevent of their local accumulation.
• Minimising irritation
