PeoGlow launched to target AGEs-RAGE pathway for clearer skin

Published: 13-May-2025
Ingredients Regulatory Skin Care

ICHIMARU PHARCOS unveils new ingredient to even tone and reduce dullness

ICHIMARU PHARCOS has launched a new cosmetic ingredient, PeoGlow, that stops the “AGEs-RAGE domino effect” for even skin tone.

One cause of skin dullness is the uneven skin tone, which results from the combination of three color tones on the skin: brown, due to Advanced Glycation Endproducts (AGEs); gray, caused by abnormal keratinisation; and black, resulting from hyperpigmentation. So, how can we address these complex contributors to uneven tone? Surprisingly, AGEs interact with the Receptor of AGEs (RAGE), triggering a signaling cascade in melanocytes and keratinocytes that induces both hyperpigmentation and abnormal keratinisation—like a domino effect. This suggests that inhibiting the AGEs-RAGE domino effect could be a simple yet powerful strategy to achieve a more even and radiant skin tone. ICHIMARU PHARCOS sought a natural material that inhibits the AGEs-RAGE interaction and discovered that an extract of Peonia albiflora roots has this ability. As a result, we launched the natural cosmetic ingredient “PeoGlow”.

PeoGlow reduces the accumulation of AGEs and blocks the AGEs-RAGE interaction, helping to achieve a more even, radiant skin tone.

Launch date: May 14th, 2025
https://www.ichimaru.co.jp/english/research/featured/247

Effects of HyaluGuard

  • Reduction of AGEs
  • Reduction of skin melanin
  • Reduction of skin age spots
  • Reduction of uneven skin tone
  • Companies:
  • Ichimaru Pharcos
See more

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