New mechanism of action discovered for Silab's Whitonyl

Published: 29-Sep-2017 Featured companies: Silab
Ingredients

Since 2007, Silab ingredient Whitonyl has been marketed as a natural de-pigmenting active ingredient thanks to its tyrosinase and melanogenesis inhibiting action, as well as its ability to inhibit stem cell factor (SCF) signalling.

However, new studies investigating the impact of the environment on melanogenesis show that Whitonyl also regulates two heretofore-unstudied pathways: the epigenome of melanocytes and communication via keratinocyte exosomes.

The Palmaria palmata extract regulates photo-induced epigenetic modifications in melanocytes by significantly boosting the expression of miRNA 145 (+59%), miRNA 218 (+33%) and miRNA 675 (+50%). It also acts on communication between keratinocytes and melanocytes.


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A French independent company, SILAB has been recognised for its expertise in skin biology and in mastering plants and biotechnologies for 40 years. It provides patented active...
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